Detection of Alzheimer's using magnetic resonance imaging (MRI) images through Machine Learning
DOI:
https://doi.org/10.47185/27113760.v4n2.121Keywords:
Artificial Intelligence, Alzheimer, Machine Learning, Neural NetworksAbstract
Alzheimer is a neurodegenerative disease that affects millions of people worldwide. This article addresses the early detection of the disease through the analysis of magnetic resonance imaging (MRI) images and the use of machine learning techniques. A comprehensive literature review was conducted on previous research in this field, which identified the current challenges and limitations in Alzheimer's detection using MRI. In particular, existing methods were found to be costly, time-consuming, and not accurate enough. Consequently, three machine learning models (SVM, decision trees, and neural networks) were trained and tested for Alzheimer's detection using MRI images. Their ability to classify images as belonging to an Alzheimer's patient or a healthy one was evaluated. The results showed that all three models achieve high accuracy in Alzheimer's detection, with the neural network offering the best performance. Moreover, the selection of relevant features was found to be crucial for improving the models' performance. The use of machine learning techniques for the early detection of Alzheimer's through MRI images is a valuable tool. The proposed models in this article demonstrate a high degree of accuracy and speed, making them effective alternatives to conventional methods.
Downloads
References
Alpaydin, E. (2020). Introduction to machine learning (3rd ed.). MIT Press.
Barakovic M, Ibrulj V, Skrbo A, et al. Machine Learning Approaches for Detection of Alzheimer's Disease: A Review. Med Arch. 2018;72(6):428-432. doi: 10.5455/medarh.2018.72.428-432
Brownlee, J. (2018). Deep learning for computer vision: Image recognition, object detection, and face recognition in Python. Machine Learning Mastery.
Belaroussi B, Milletari F, Navab N. Deep Learning-Based Multi-modal Fusion for Alzheimer’s Disease Diagnosis. In: Ourselin S., Joskowicz L., Sabuncu M.R., Unal G., Wells W. (eds) Medical Image Computing and Computer Assisted Intervention – MICCAI 2018. MICCAI 2018. Lecture Notes in Computer Science, vol 11072. Springer, Cham. doi: 10.1007/978-3-030-00928-1_31
Cuingnet, R., Gerardin, E., Tessieras, J., Auzias, G., Lehéricy, S., Habert, M. O., ... & Colliot, O. (2011). Automatic classification of patients with Alzheimer’s disease from structural MRI: A comparison of ten methods using the ADNI database. Neuroimage, 56(2), 766-781.
Eskildsen SF, Coupé P, García-Lorenzo D, et al. Prediction of Alzheimer's disease in subjects with mild cognitive impairment from the ADNI cohort using patterns of cortical thinning. Neuroimage. 2013;65:511-521. doi: 10.1016/j.neuroimage.2012.09.058
Feng, Y., Li, L., Zhang, Y., & Zhang, Y. (2018). Early Diagnosis of Alzheimer’s Disease Based on Resting-State Brain Networks and Deep Learning. Frontiers in Neuroscience, 12, 331. https://doi.org/10.3389/fnins.2018.00331
Grau-Rivera, O., Operto, G., Falcón, C., Brugulat-Serrat, A., Suárez-Calvet, M., Salvadó, G., ... & Molinuevo, J. L. (2021). Early diagnosis of Alzheimer’s disease: A multidisciplinary approach. Journal of Alzheimer's Disease, 79(2), 525-535. https://doi.org/10.3233/JAD-201262
Guo Y, Zhang Y, Zhu X, et al. Classification of Alzheimer's Disease Using Whole Brain Hierarchical Network. In: Fichtinger G., Martel A., Peters T. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2017. MICCAI 2017. Lecture Notes in Computer Science, vol 10433. Springer, Cham. doi: 10.1007/978-3-319-66179-7_47
Koutsoumpakis C, Leifert W, Stieler J, et al. Automated MRI-based classification of Alzheimer’s disease using individualized feature selection with ensemble learning. Neurocomputing. 2018;275:2483-2491. doi: 10.1016/j.neucom.2017.10.053
Liu S, Liu S, Cai W, et al. Multimodal Neuroimaging Feature Learning for Multiclass Diagnosis of Alzheimer's Disease. IEEE Transactions on Biomedical Engineering. 2015;62(4):1132-1140. doi: 10.1109/TBME.2014.2385145
Liu, S., Liu, S., Cai, W., Pujol, S., Kikinis, R., & Feng, D. (2020). Early diagnosis of Alzheimer’s disease with deep learning. Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops, 2020, 2715-2724. https://doi.org/10.1109/CVPRW50498.2020.00330
Maggipinto T, Bellotti R, Altomare D, et al. MRI classification of Alzheimer's disease: a two-stage approach. IEEE J Biomed Health Inform. 2015;19(5):1551-1561. doi: 10.1109/JBHI.2014.2371434
Mendelson, Z. S., & Haughton, V. M. (2017). The Use of Machine Learning Techniques in Brain Magnetic Resonance Imaging: A Review. Journal of Neuroscience Methods, 301, 85-92. https://doi.org/10.1016/j.jneumeth.2017.07.008
Moradi, E., Pepe, A., Gaser, C., Huttunen, H., Tohka, J., & Alzheimer's Disease Neuroimaging Initiative. (2015). Machine learning framework for early MRI-based Alzheimer’s conversion prediction in MCI subjects. Neuroimage, 104, 398-412.
Organización Mundial de la Salud. (2021). Demencia. Recuperado de https://www.who.int/es/news-room/fact-sheets/detail/dementia
Sato JR, Hoexter MQ, Fujita A, et al. Machine-learning classification of OCD patients based on diffusion-weighted imaging tractography data. J Psychiatr Res. 2012;46(9):1124-1130. doi: 10.1016/j.jpsychires.2012.05.001
Schouten TM, Koini M, de Vos F, Seiler S, van der Grond J, Lechner A. Combining anatomical, diffusion, and resting state functional magnetic resonance imaging for individual classification of mild and moderate Alzheimer's disease. Neuroimage Clin. 2016;
World Health Organization. (2019). Dementia. Retrieved from https://www.who.int/news-room/fact-sheets/detail/dementia
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 laura paulina noreña correa
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.